What is gymnema sylvestre

Animal testing confirms that gymnema reduces blood glucose levels. Lab rats given gymnema extract also eat less and lose weight. Unfortunately, the research on humans is all but non-existent. And, as we know all too well, what works for lab rats does not always work for humans.

Already a subscriber? Sign in. Thanks for reading Scientific American. Create your free account or Sign in to continue. See Subscription Options. Keywords: Gymnema sylvestre, antidiabetic, obesity, Gymnemic acids, herbal drug. Introduction Gymnema sylvestre G. Plant description G. Open in a separate window. Phytochemistry of G. Mechanism of Action of Gymnemic Acids Gymnemic acid formulations have also been found useful against obesity, according to recent reports [ 10 ].

Diabetes Mellitus Diabetes mellitus can be defined as a group of syndromes characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins along with an increased risk of complications from vascular disease.

Herbal medicines for treatment of diabetes The Indian subcontinent has given to the medicinal world, natural remedies such as Ayurveda , Yunani and Siddha. Obesity and Its Impact on the Human Body Obesity, technically, is characterized by the increased storage of tri glycerides fat molecules in the adipose tissue thereby causing insulin resistance.

Exploring the link between obesity and diabetes It is a well-known fact that molecular mechanisms underlying the link between obesity and diabetes have been elusive, but new research studies show that there could be a enzymatic link between the two most common metabolic disorders [ 23 ]. Hypothesis Linkage between obesity, diabetes, Gymnemic acids : a possible linkage From the above aspects of the diseases i. Conclusions Although there are many phytoconstituents that could combat diabetes and obesity, a single phytoconstituent that could be used in the treatment of both the diseases simultaneously would be a welcome addition.

References 1. The Wealth of India. Raw materials, vol. A Dictionary of Indian Raw materials and Industrial products; pp.

Komalavalli N. In vitro micropropagation of Gymnema sylvestre : multipurpose medicinal plant. Plant Cell, Tissue and Organ Culture. Dateo G.

Gymnemic acid, the antisaccharine principle of Gymnema sylvestre. Studies on isolation and heterogenesity of gymnemic acid A 1. Food Chem. Liu H. Isolation and structure elucidation of Gymnemic acids, antisweet principles of Gymnema sylvestre.

Sinsheimer J. Constituents from Gymnema sylvestre leaves. Constituents from Gymnema sylvestre leaves VIII: Isolation, chemistry and derivatives of gymnemagenin and gymnestrogenin. Constituents from Gymnema sylvestre Leaves V: Isolation and preliminary characterization of Gymnemic acids.

Yoshikawa K. Structure studies of new antisweet constituents from Gymnema sylvestre. Sahu N. Triterpenoid Saponins from Gymnema sylvestre. Kanetkar P.

Mysore, India: Gymnemic acids: A molecular perspective of its action on carbohydrate metabolism. Persaud S. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. Nakamura Y. Fecal steroid excretion is increased in rats by oral administration of gymnemic acids contained in Gymnema sylvestre leaves.

Agarwal S. Chemistry and medicinal uses of Gymnema sylvestre gur-mar Leaves: A Review. Indian Drugs. Khare A. Hypoglycemic activity of an indigenous drug Gymnema sylvestre in normal and diabetic persons.

Maeda M. Studies on taste modifiers II: Purification and structure determination of gymnemic acids, antisweet active principle from Gymnema sylvestre leaves. Manni P. Dahanukar S. Pharmacology of medicinal plants and natural products. Indian J. Ramachandran A. Type 2 diabetes in Asian-Indian urban children. Diabetes Care. Gymnema sylvestre : A Memoir. Kang, J. Effect of gymnemic acid on the elevation of blood glucose concentration induced with oral sucrose in streptozotocin-diabetic rats.

Hanyang Uidae Haksulchi 10 1 , — Kang, M. Hypoglycemic Activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats. Kapoor, L. Kar, P. Amelioration of Cyclophosphamide induced immunosupression by the hydro-alcoholic extract of Gymnema sylvestre leaves in albino rats.

Karthikeyan, M. Enhancement of antibacterial and anticancer properties of pure and REM doped ZnO nanoparticles synthesized using Gymnema sylvestre leaves extract.

SN Appl. Kashima, H. Senses 42 4 , — Kaur, N. Stigmasterol: a comprehensive review. Kazemipoor, M. Food Prop. Khanna, G. Non-proliferative activity of saponins isolated from the leaves of Gymnema sylvestre and Eclipta prostrata on HepG2 cells-In vitro study. Khare, A. Khramov, V. Chemical composition of dry extracts of Gymnema sylvestre leaves. Kirtikar, K. Indian Medicinal Plants. Lalit Mohan Basu, Allahabad. Jayyd Press, New Delhi, India, 2, Kishore, L. Protective effect of Gymnema sylvestre L.

Homoeopathy 9 4 , — Kosta, S. Screening and assessment of anti-diabetic and reactive oxygen scavenging ros , effects of herbs in streptozotacin induced mice. Kothe, A. Kumar, A.

Evaluation of Anti-inflammatory Activity of some selected species of Asclepiadaceae Family. Kumar, P. Kumar, S. Kumar, V. Antidiabetic and hypolipidemic activity of Gymnema sylvestre in dexamethasone induced insulin resistance in Albino rats. Drug Res. Li, Y. Effect of Gymnema sylvestre , Citrullus colocynthis and Artemisia absinthium on blood glucose and lipid profile in diabetic human.

Acta Pol. Liu, B. Liu, H. Liu, X. Two new flavonol glycosides from Gymnema sylvestre and Euphorbia ebracteolata. Liu, Y. Chemical constituents from the stems of Gymnema sylvestre.

Luo, H. Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome animal. Cell Biochem. Malik, J. Anti-arthritic activity of leaves of Gymnema sylvestre R. Mall, G. Antidiabetic and hypolipidemic activity of Gymnema sylvestre in alloxan induced diabetic rats. Mao, Q. Role of the breast cancer resistance protein ABCG2 in drug transport. AAPS J. Marakis, G. Risk assessment of substances used in food supplements: the example of the botanical Gymnema sylvestre.

EFSA Journal 16 51 , e Mathew, M. Indian Coconut J. Cochin 34 10 , 10— Matsuda, H. Mcburney, D. Senses 3 1 , 45— Nadkarni, K. I Bombay, India: Popular Prakashan , — Najafi, S.

Studies on Gymnema sylvestre -a medicinally important plant of the family Asclepiadaceae. Nakamura, Y. Ogawa, Y. Food Hyg. Ohmori, R. Antioxidant activity of various teas against free radicals and LDL oxidation. Lipids 40 8 , — Pasha, C.

Antisalmonella Activity of Selected Medicinal Plants. Turkish J. Patel, M. Pharmacognostic and Phytochemical Evaluation of Gymnema sylvestre Leaf. World J. Paul, J. Screening of antibacterial effects of Gymnema sylvestre L. Porchezhian, E. An overview on the advances of Gymnema sylvestre : chemistry, pharmacology and patents. Pharmazie 58 1 , 5— Potawale, S.

Gymnema sylvestre : a comprehensive review. Pramanick, D. Preuss, H. Rachh, P. In-vitro evaluation of antioxidant activity of Gymnema sylvestre R.

Plant Biol. Antihyperlipidemic Activity of Gymenma sylvestre R. Rahman, M. Comparative assessment on In vitro antioxidant activities of ethanol extracts of Averrhoa bilimbi , Gymnema sylvestre and Capsicum frutescens.

Ramalingam, R. Rouhi, S. The effect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers, and the histopathology of pancreatic islets of Langerhans in streptozotocin-nicotinamide induced type 2 diabetic Sprague—Dawley rats. BMC Complement. Rupanar, S. Phytochemical screening and In vitro evaluation of antioxidant antimicrobial activity of Gymnema sylvestre.

Sahu, N. Triterpenoid saponis from Gymnema sylvestre. Sarker, M. Antihyperglycemic, insulin-sensitivity and anti-hyperlipidemic potential of Ganoderma lucidum, a dietary mushroom, on zalloxan-and glucocorticoid-induced diabetic Long-Evans rats.

Food Health Dis. In vitro enhancement of polyclonal IgM production by ethanolic extract of Nigella sativa L. Bangladesh Pharm. Preliminary screening of six popular fruits of Bangladesh for in vitro IgM production and proliferation of splenocytes. Promotion of anti-keyhole limpet hemocyanin IgM and IgG antibody productions in vitro by red bell pepper extract.

Foods 5 4 , — Sastry, B. Gymnema sylvestre. Sathya, S. Hypoglycemic effect of Gymnema sylvestre retz. Br leaf in normal and alloxan induced diabetic rats. Life 28 2 , 12— Senthilkumar, M. Ex Schult. Shafey, A. Effect of Gymnema sylvestre R. King Saud. Shah, K. In vitro permeation of aceclofenac through the shed skin of two different species. Pharmacia Sinic. Transdermal delivery of aceclofenac: Effect of Gymnema sylvestre and Caralluma adscendens with its mechanism of action.

Shah, M. Antidiabetic potential of Brassica Oleracea Var. Italica in type 2 diabetic sprague dawley sd rats. Shankar, K. Anti-arthritic activity of Gymnema sylvestre root extract. Asia 5 1 , — Shanmugasundaram, E.

Effect of an Isolate from Gymnema sylvestre , R. Life 7 3—4 , — Possible regeneration of the islets of langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. Sheikh, B. Prophetic medicine as potential functional food elements in the intervention of cancer: A review. Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT and HT29 cell lines.

Shenoy, R. In vitro antidiabetic effects of isolated triterpene glycoside fraction from Gymnema sylvestre. Based Complement. Shigematsu, N. Effect of administration with the extract of Gymnema sylvestre R. Br leaves on lipid metabolism in rats. Effect of long term-administration with Gymnema sylvestre R. Shimizu, K. Suppression of glucose absorption by some fractions extracted from Gymnema sylvestre Leaves. Shivanna, Y. Invitro antibacterial effect of selected medicinal plant extracts.

India 2, 64— Shiyovich, A. Toxic hepatitis induced by Gymnema sylvestre , a natural remedy for type 2 diabetes mellitus.