When first starting treatment, your healthcare provider will want to monitor for signs of respiratory depression for the first 24 to 72 hours and do the same if the dose is ever increased. This may involve an arterial blood gas test or pulse oximetry to measure oxygen saturation levels. This is especially important for people with cancer, who are often prescribed the drug to treat chronic pain.
Tylenol 3 can be taken with or without food. If taking the oral solution, be sure to shake the bottle thoroughly before use.
Always measure the oral solution with a medication-measuring device, which you can get from your healthcare provider or pharmacist. Avoid "eyeballing" doses, as this can lead to overdosing. Tylenol 3 tablets or oral solution can be stored at room temperature, between 68 F and 77 F 20 C to 25 C. It is best to keep the medication in a cool, dry room in its original light-resistant container.
Never use a drug past its expiration date. Be sure to keep this medication out of reach of children or pets. Tylenol 3 can cause a number of side effects related to acetaminophen or codeine.
Some are low-grade and tend to resolve on their own without treatment. Others are severe and may require the discontinuation of treatment. Less commonly, diarrhea, abdominal pain, cramps, fainting, heart palpitations, insomnia, nervousness, and fatigue may occur. Adrenal insufficiency reduced adrenal gland function can develop when opioids are used for longer than one month.
Symptoms include nausea, vomiting, loss of appetite, fatigue, weakness, and dizziness. The gradual discontinuation of Tylenol 3 along with the short-term use of oral corticosteroid drugs to support adrenal function can usually set things right.
Even in healthy adults, high doses of acetaminophen can cause liver injury. Taking 4, mg within 24 hours can significantly increase the risk of hepatoxicity liver poisoning and permanent liver damage. Taking two tablets of Tylenol 3 every four hours pushes you uncomfortably close to that daily limit 3, mg. Drinking alcohol while taking acetaminophen significantly amplifies the risk of liver damage.
On rare occasions, Tylenol 3 has also been known to cause a potentially life-threatening, whole-body allergic reaction known as anaphylaxis.
In most cases, codeine is the responsible culprit, triggering symptoms within minutes of taking a dose. Call or seek emergency care if you experience some or all of the following after taking Tylenol If left untreated, anaphylaxis can lead to shock, coma, asphyxiation, heart or respiratory failure, and even death.
Tylenol 3 should be used with caution in certain groups. The drug may not be contraindicated, per se, but specialist insight may be needed to determine how appropriate the drug is on a case-by-case basis for people with some conditions.
Some people with epilepsy , for example, may experience a greater frequency of seizures when taking Tylenol 3. Elderly people with reduced kidney function may also experience seizures. Because there is no way to know who might be affected, healthcare providers should monitor those with a risk of seizures and discontinue treatment if seizures occur or worsen.
Because of the stress acetaminophen can place on the liver, people with chronic liver disease should limit their daily intake to no more than 2, mg per day, according to the American College of Gastroenterology, or even less if severe liver disease is present. In addition, even if you don't have liver disease, always use the smallest amount of acetaminophen possible. The risk of respiratory depression and death is greater when Tylenol 3 is taken with benzodiazepines and other drugs including alcohol that suppress the central nervous system.
To avoid this, most healthcare providers will simply find alternatives to Tylenol 3. If this is not possible and there are no reasonable alternatives for chronic benzodiazepine users such as people with generalized anxiety disorder , panic disorder , or agoraphobia , the lowest possible dose should be used for the shortest amount of time under constant medical supervision.
Tylenol 3 can also interact with a wide range of drugs that use the enzyme cytochrome P CYP for metabolism. Tylenol 3 also utilizes CYP, and, by taking these drugs together, you might experience increases or decreases in blood concentration of one or both drugs. Decreased drug concentrations are associated with a loss of clinical effects, while increased drug concentrations correspond to a worsening of side effects. With Tylenol 3, any drug interaction that causes a drop in blood concentration can lead to significant and sometimes profound opioid withdrawal symptoms.
Among some of the drugs at the greatest risk of CYP interactions are:. Due to the severity of the interaction, Tylenol 3 should not be used with any of these drugs. There are literally dozens of other drugs that can interact with Tylenol 3. Some of these interacting medications may require a dose adjustment or the separation of doses by one to six hours.
To avoid drug interactions, always let your healthcare provider know about any drugs you are taking, whether they are prescription, over-the-counter, herbal, or recreational. One of the primary concerns about the extended use of Tylenol 3 is the risk of opioid addiction and abuse.
Equally concerning are withdrawal symptoms that can arise when treatment is suddenly stopped. Doing so can cause an array of side effects, including nausea, vomiting, diarrhea, sweating, abdominal cramping, agitation, and a rapid return of pain. To avoid this, your healthcare provider will place you on a drug-tapering schedule to gradually wean you off the drug. If you are unable to quit Tylenol 3 and have signs of physical or mental dependence, speak with your healthcare provider about a drug treatment program to help you overcome the addiction.
Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Janssen Pharmaceuticals. This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions. If you think you or someone else may have taken an overdose of this medicine, get emergency help at once.
Signs of an overdose include: dark urine, difficult or trouble breathing, irregular, fast or slow, or shallow breathing, nausea, vomiting, pain in the upper stomach, pale or blue lips, fingernails, or skin, pinpoint pupils of the eyes, or yellow eyes or skin.
This medicine may cause sleep-related breathing problems eg, sleep apnea, sleep-related hypoxemia. Your doctor may decrease your dose if you have sleep apnea stop breathing for short periods during sleep while using this medicine. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.
Using this medicine while you are pregnant may cause serious unwanted effects, including neonatal withdrawal syndrome in your newborn baby.
Tell your doctor right away if your child has the following symptoms: an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, sneezing, weight loss, vomiting, yawning, or failure to gain weight. Check with your doctor right away if you think you are pregnant or if you plan to become pregnant while using this medicine. Codeine is changed to morphine in the body. Some people change codeine to morphine more quickly than others.
These individuals are called "ultra-rapid metabolizers of codeine". Contact your doctor immediately if you experience extreme sleepiness, confusion, or shallow breathing. These symptoms may indicate that you are an "ultra-rapid metabolizer of codeine". As a result, there is too much morphine in the body and more side effects of morphine than usual. Children may be especially sensitive to this effect. Do not give this medicine to:. If a nursing mother is an ultra-rapid metabolizer of codeine, it could lead to morphine overdose in the nursing baby and cause very serious side effects.
This medicine may cause serious allergic reactions, including anaphylaxis, angioedema, or certain skin conditions Stevens-Johnson syndrome. These reactions can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, blistering, peeling, or loosening of the skin, fever or chills, trouble breathing or swallowing, or any swelling of your hands, face, mouth, or throat while you are using this medicine.
Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help. Also, lying down for a while may relieve dizziness or lightheadedness. This medicine may make you dizzy, drowsy, confused, or disoriented. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. This medicine will add to the effects of alcohol and other CNS depressants medicines that can make you drowsy or less alert.
Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, other prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.
Also, there may be a greater risk of liver damage if you drink 3 or more alcoholic beverages while you are taking acetaminophen. Do not drink alcoholic beverages, and check with your doctor before taking any of these medicines while you are using this medicine.
Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.
Do not change your dose or suddenly stop using this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping.
Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there.
These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body. Before you have any medical tests, tell the medical doctor in charge that you or your child are taking this medicine.
The results of certain tests may be affected by this medicine. Using too much of this medicine may cause infertility unable to have children. Talk with your doctor before using this medicine if you plan to have children.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal or vitamin supplements. Along with its needed effects, a medicine may cause some unwanted effects.
Although not all of these side effects may occur, if they do occur they may need medical attention. It's important to let the lab clinician know if you have eaten anything or taken any medications or supplements that might affect your results.
How long Tylenol 3 is detectable in your body depends on a variety of factors, including the dosage and how often you use the medication as well as your weight, age, metabolism, and overall health. Older adults tend to clear the drug at a slower pace than younger adults. Your metabolic rate, which can be influenced by age, activity level, and overall health, influences the detection time of Tylenol 3.
In general, the slower your metabolism, the longer the drug will remain in your system. Because the liver and kidneys both play a role in the metabolism of the drug, impaired liver and kidney function can mean that it takes longer to metabolize Tylenol 3.
A higher dose of Tylenol 3 will take longer to process and excrete than a lower dose. Similarly, if you've been taking the drug for some time, it will take longer to clear your system.
Like other drugs, the best way to get Tylenol 3 out of your system is to stop using the drug and give your body time to process and eliminate it. Staying well-hydrated and getting regular exercise can't hurt but this doesn't mean that sweating out or flushing out the drug with tons of water will help.
This method will only dilute the drug test and you'll likely have to retake it. If you plan to stop using the drug, work with your doctor. It's best to taper off of prescriptions containing codeine in order to avoid unpleasant withdrawal symptoms. Codeine also can be extremely dangerous if there's too much of the drug in the body at once, whether it's taken alone or as an active ingredient in Tylenol 3. The same may be true of acetaminophen even though it's a non-narcotic pain reliever, but for different reasons.
If you take the medication exactly as your doctor prescribed and you're careful to not take another drug that could interact with acetaminophen or codeine, you shouldn't have any problems taking Tylenol 3. Still, it's good to be aware of the following symptoms of a potential overdose:. Symptoms of Tylenol 3 overdose may not be evident right away, but may include:. If you suspect that you or a loved one may be experiencing an overdose, call or seek medical help immediately.
Acetaminophen has a narrow safety range. If you take more than 4, milligrams per day, you risk irreversible liver damage that ultimately can lead to death. Damage and overdose can happen more easily than you might think because acetaminophen is an ingredient in many different combination medications, such as cold or allergy drugs designed to target multiple symptoms. For this reason, combination medications like Tylenol 3 are limited to no more than milligrams of acetaminophen per tablet, capsule, or other dosage unit.
Before you take another medication, read the ingredient list carefully. If the medication contains acetaminophen or paracetamol as it's known in Europe and the UK , note how many milligrams there are per dose. Do the math to make sure you don't exceed 4, milligrams in a hour period. Safer yet, talk to your doctor or pharmacist before taking Tylenol 3 and another product containing acetaminophen.
Codeine may also cause serious breathing problems in some individuals, especially during the first day or two of taking it. In fact, it's generally recommended that people who have conditions such as asthma or chronic obstructive pulmonary disease COPD use codeine with significant caution. Codeine can interact with other medications and substances, too. Because it affects the central nervous system, you should be careful not to take other drugs that can slow breathing or cause drowsiness while taking Tylenol 3, or before it's likely to have cleared from your system.
Do not drink alcohol while using Tylenol 3. Also, you shouldn't take other medications that contain acetaminophen or that might have sedative properties, including:. Tell your doctor about all prescription, non-prescription, and over-the-counter medications you're taking so they can check for interactions and adjust dosages as needed.
Having too much codeine in the body poses several risks. For one, the drug can be habit-forming, meaning it could cause a person to develop a dependence. If you've been taking Tylenol 3 for several weeks or longer and want to stop, talk to your doctor. They can help you taper off the drug safely by decreasing your dose slowly.
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